I haven't had a chance to try Opus 5 yet but Fable currently refuses to do anything in my field (radiology image analysis). It didn't used to be that way but that has been the reality the last two weeks or so. Fable has been useless they might as well drop it as far as I am concerned.
I'm more on the clinical physics side building tools for scanner/equipment QA and data handling/workflow automation/de-identification and anonymization but I also build random little tools to help optimize acquisition parameters.