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Tragically this won't be the last time AI kills a lot of innocent people.

This is not AI killing poeole, this is US government killing poeole.

AI didn’t kill innocent people here, the Department of Defense and its decision-makers did.

Fable and now Opus 5.5 won't answer my college student's prompt about Alzheimer's and immune response.

ChatGPT 6 Pro answered it without issue.


I am honestly still confused about this limitation. I can understand cybersecurity, because mass "hacking" can be automated and Claude itself can help you do it, but biology...? Is it that easy to manufacture and distribute viruses and whatnot?

I imagine some terrorists in a cave with a lenovo laptop manufacturing bio weapons with some flasks and Claude

Right next to the hypersonic missile vibecoder

You can order genes online, and some say you can assemble using stuff cobbled together in a home lab rather easily. For the last 20 years, I've personally felt that bio-terrorism is the highest possible risk, well above nuclear, or chemical warfare. But it does take training, expertise, or, it did.

Then stop selling genes online?

It’s like saying you sell ammonium nitrate and fuel oil online and then saying it’s too risky to let people have computers in case they use them to make ANFO. They can only make bioweapons because you’re selling them bioweapon components! They can’t make genes at home!


Considering there are many high-school competitions in genetic editing, some listed at [0] as well as a whole biohacker culture, and labs providing gene sequencing as a service e.g., [1,2], we can reasonably assume it is not beyond the reach of some garage lab to accidentally or deliberately spread a deadly pathogen if it can find the right sequence.

So, yes, having an unconstrained frontier AI doing the searching and analysis to find the right (i.e., wrong and deadly) sequence would massively increase the odds some garage biohacker or small aggrieved nation-state starting the next pandemic.

[0] https://www.sciencebuddies.org/projects-lessons-activities/g...

[1] https://www.genewiz.com/public/services/sanger-sequencing

[2] https://plasmidsaurus.com/


Fable 5.1 refuses to answer my college student's prompt about Alzheimer's and immunology.

It always downgrades to Opus 4.8 because apparently solving Alzheimer's should be left to big pharma?


In other news, Cantor Fitzgerald lost about 150 information-technology workers when the north tower collapsed on this day 25 years ago.

[flagged]


I don’t see a single comment I would describe as celebrating this


870+ comments not blocked on its prior listing here eight days ago.

https://news.ycombinator.com/item?id=49337392


My Dell rep quoted me $736 for a single 16GB RDIMM for the newer Dell Pro 16 laptop, which retails at its baseline configuration with 16GB for ~$1000.


Dell wants $4,507 (web price) for each 32GB RDIMM in a PowerEdge 6625 (16GB is showing as unavailable)


Pre-ACA, I could afford family insurance. My family premiums went up ~$500 a month post-ACA, while the coverage worsened.

My afib ER trip three years ago cost me $7k out of pocket even though I left the hospital still in afib.

Today in my 50s, my deductible is now $8,500. My partner doesn't have insurance because she's not poor enough or rich enough.

We had an insurance rep come to my work last year who said after ACA they had some people whose premiums went up 900%.

So yeah, ACA is better in your world, but not in mine.


Yeah, since the ACA my coverage has remained the same while my costs have risen 10x; I'm in my 30s and my medical insurance costs 3x what my mortgage costs, and I still have $$$$ sized bills after a round of strep throat.

I would really like to just be able to get a true catastrophic policy which would cover unlikely risks such as cancer -- and then go on a cash basis for common meds and treatments. The ACA made this kind of insurance illegal, so my choice is to leave my family uninsured -- or let insurance soak up the money I might have saved for their college education.


Your blame is misplaced. Costs are increasing in spite of the ACA, not because of it. Pre-ACA your family insurance policy was likely worse in some key ways: it probably excluded coverage pre-existing conditions and had a lifetime maximum coverage limit.


But then the blame might be correctly placed? If he had no pre-existing conditions and was on a no-existing conditions plan, that plan might have saved him a lot of money.

Imagine car insurance regulations changing in such a way to force underwriters to blanket-assume everyone has had a couple speeding tickets this year. I understand why we do it. We are ok with speeders paying more for insurance, and not ok with someone born with diabetes forced to pay more for health insurance. But it is the end result in any case.


Pretty much everyone who lives long enough will end up with some sort of pre-existing condition.


It's almost like the real problem is hospital and medical costs versus cost of living.

)which is why as a percentage of GDP, Americans, European costs are remarkably similar, just distributed differently).


So you support single payer where none of that exists?


Yep. We were promised it would save us money. Instead, healthcare care costs skyrocketed thanks to Obamacare.


George Bird Grinnell, the "Father of Glacier National Park", made a final visit to his namesake Grinnell glacier in 1926 and then wrote in his diary [1]:

>"the glacier is melting very fast and the amount of water coming from it is great. All these glaciers are receding rapidly and after a time will disappear."

[1] = https://www.nps.gov/articles/000/repeat-photos-of-grinnell-g...


It's important to also note, as explained in the article: >"Grinnell was witnessing the glacier react to a relatively natural change in the climate. The Little Ice Age, which was a cold period when the park’s current glaciers were at their largest, ended in the late 1800s as the climate started warming. The melting of the park’s glaciers in the late 1800s, was a mostly natural reaction to the end of the Little Ice Age."

The quote, without context, implied to me that he had an understanding of anthropogenic climate change a century ago. While there were people[1] at that time who did theorize this was happening, I don't think that's what Grinnell was implying in his diary.

It's also the case that the amount of melting then pales in comparison to the amount occurring today - so I'm not attempting to say that what we see today may be the continuing of a natural climate fluctuation.

1. https://en.wikipedia.org/wiki/Nils_Gustaf_Ekholm


I was at Glacier Bay National Park just last week (https://photos.prakhar.me/alaska) and it was just depressing to hear from the park rangers on how far the glaciers have receded. Really grateful to have been able to witness them in person but it is sad to see what we've done to this planet.


I don't know you but I doubt you're largely responsible for the climate crisis. What I mean is that the "we" is a unsteerable concept. As such, I don't consider myself responsible. I do as much as my limited power lets me (also i guess I could resort myself to more potent ways of political expression). People that have power are responsible.


The Glacial National Park referenced by GP is in Montana; you were perhaps at Glacier Bay National Park.

Regardless, some beautiful photos, thanks for sharing


Please fix the inflammatory clickbait title to the actual Guardian headline:

Greenland issues ‘strong warning’ as Trump-linked oil firm prepares to drill


the timetable in the article is completely wrong or has been radically accelerated

that massive 300 container delivery due in September and then drilling in October has already been completely unloaded NOW, months ahead

there's no "prepare" it's already in progress


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