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Meanwhile someone went and did the experiment on the equivalent problem in a virus: https://www.science.org/content/blog-post/mutate-em-all-and-...

And various dedicated AI models all made poor predictions of the results of that experiment, which casts doubts about the value of the AlphaGenome predictive map.

A virus is much simpler than a human, but even for that simple virus the effects of most of the mutations could not be predicted. A half of the mutations had harmful effects, and for a half of those it is unknown for now why they were harmful.

For a human the uncertainty about the effects of a mutation will be far greater than for one of the simplest viruses.


Vampires aren't any more fantastical than FTL travel, and yet we're perfectly happy to have that in SF.

I agree the line between fantasy and sci Fi is very thin. In general I would say if the author intends for it to be a natural explanation like wormholes or something it's sci fi, if it's a magic teleportation spell it is fantasy. There is a series I read once Starships Mage which plays with this, it's hard sci fi for most things but magic exists and FTL is solved through teleportation. Everything non magic has to obey relativity and such.

> Twinkle Twinkle Little Star. .... 100%

That's certainly a revealing example. TTLS is entirely melody, and the article says basically nothing about melody. At a stretch you could say "the article talks about the major scale, TTLS uses notes from a major scale" and if your conclusion is "that's why I like it", then you should feel the same way about any permutation of the notes in TTLS, or indeed anything you get from hitting the white notes on a piano one at a time.


> the article says basically nothing about melody

Its 13 mentions of melody sufficed for me.


Most of those are variable names. The rest: > Why a melody wants to land where it lands is still mostly opaque to me

> A key, its diatonic chords, a progression, those chords broken into an arpeggio one note at a time, and a melody that sticks to the scale

> Change the melody array to anything at all and it will still fit

The first part of TTLS (in C) is: C C G G A A G F F E E D D C. Let's follow the guidance of this last part and change the "melody array"; for neatness we can alphabetize it: A A C C C D D E E F F G G G. Now that you understand melody, please tell me why even though it "still fit"s it doesn't sound as nice.


"Seem" is doing a lot of work there.

> But what about

At the very least your dog stands a good chance of being put down.



The only instance of tradition on that page says it is contained within plays and literature. This is different than saying that the actual act itself, in real life, was a tradition.

The reasonable thing to do is look up the ja.wiki

Here's one citation (14-15 double suicides a year Taisho era in some fashionable district)

https://hdl.handle.net/20.500.14094/0100275627

I agree that suicide ideation is not exactly prosocial, but I think being tolerant of misinformation is a worse look on HN?


Ah, the good old "outside agitators" canard.

> These new AI data centers are now built with their own power generation capacity

And now you've got all the noise and pollution from that to deal with.


Some of the data centers build out solar, most are natural gas turbines.

The outside agitators are in the news. The U.S. just happens to be a little more vulnerable to "straight to the people" propaganda campaigns.


Propaganda, which the largest corporations on earth, including news media behemoths, would never, ever stoop to. Right?

It's a big world, and I personally don't know anything about the history of software in places other than the west. Could you expand on the particulars of software in China and why those claims are wrong?

> Known as the "godfather" of programmers in the internet era

Well, was he? I mean, I never heard of him, but all I know about the Chinese internet from those years I got from reading China Smack.

I can't speak to computing history in China, but Read Only Memory has books about the Japanese [0] and British [1] video game companies. MIT has published books about computing in Taiwan, Bulgaria, and China [2]. The former two are even open access, so you can download them for free.

[0] https://readonlymemory.com/products/japansoft-an-oral-histor...

[1] https://readonlymemory.com/products/britsoft-an-oral-history

[2] https://direct.mit.edu/books/search-results?f_ContentType=Bo...


What does any of this have to do with Chen Danyan?

> good thing it's completely illegal for the federal government to interfere with state voting proceedure

Oh yeah that'll stop them.


400 years ago you'd be saying the same thing about heliocentrism.

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